ASSOCIATION STUDY OF MIR-146A RS2910164 AND RS57095329 POLYMORPHISMS WITH RISK OF BEHCET’S DISEASE

Abstract

Background & Aims: Behcetchr('39')s disease (BD) is an autoimmune disease that usually occurs with oral, genital and ocular ulcers. The cause of this disease is unknown and environmental, genetic and immunological factors contribute to its development. In the present study, the relation between rs2910164 and rs57095329 polymorphisms of miR146a gene with the potential for BD was investigated in Iranian population. Materials & Methods: In this case-control study, 100 patients with Behcetchr('39')s disease and 100 Normal with no history of disease were studied as control. The polymorphism rs2910164 was determined by PCR-RFLP method using the MnlI enzyme, and the polymorphism rs57095329 was determined by the ARMS PCR method for genotype. The data were analyzed using SPSS version 22. Results: The prevalence of GG genotype in rs2910164 polymorphism showed no significant difference between patient and control groups (p=0.156). The Frequency of the genotype AA was also not significantly different in the rs57095329 polymorphism in both patient and control groups (p=0.814). Conclusion: In this study, there was no significant relationship between rs2910164 and rs57095329 polymorphisms and the potential for BD. Research on a greater number of patients can be effective.