Evaluation of the antibiotic susceptibility of Coagulase Negative Staphylococci in children

Abstract

Ghotaslou R1, Gharashi Z2, Pour-asl M3 1. Assistant professor, Department of pathobiology, Faculty of medicine, Tabriz University of medical sciences 2. Associate professor, Department of pediatrics, Tabriz University of medical sciences 3. Instructor, Department of pathobiology, Faculty of health, Tabriz University of medical sciences Abstract Background: The most common microorganism in blood cultures is Coagulase Negative Staphylococci (CNSt). Exact diagnosis of bacterial agents in blood and their antibiograms are an important value in septicemia therapy. The purpose of the present study is to identify and determine antibiotic susceptibility of CNSt isolated from blood in children. Materials and methods: Samples were collected from 270 patients with CNSt positive blood cultures during 2 years (2003-2004) in pediatric center of Tabriz by routine microbiological methods. The disc agar diffusion technique (kriby-Bauer) was used to evaluate the susceptibility test of CNSt. Results: In our study mean age of patients was 10 month. 54.4% and 45.6% were male and female repectively. In 270 CNSt, the resistance to Penicillin, Ampicilline, Cephalexin, Ceftizoxime, Ceftriaxon and Vancomycin were respectively 98.1%, 95.9%, 62.3%, 55.9%, 53.7% and 2.6%. Conclusion: Antibiotic susceptibility of CNSt is not predictable and multiresistant strains are common. Vancomycin is the drug of choice, since only 2.6% resistant CNSt were noticed.