Comparing the effects of IV infusion of 10% dextrose and 40 IU/L of oxytocin on uterine contraction after Cesarean section

Abstract

Background: Uterine bleeding is an important side effect of cesarean section which is due to non contractile uterine. The aim of this study was to compare the effect of 10% dextrose (IV infusion) and 40 IU/L oxytocin (IV infusion) on uterine contraction. Materials and Methods: This research was a double-blinded randomized clinical trial (RCT) study. 120 women were equally included in the two study groups. After cesarean section and uterine bleeding due to non contractile uterine, each patient randomly received 10% dextrose or 40 IU/L oxytocin in equal volume, intravenously. The ability of these two drugs to induce firm contraction of the uterine muscle was then determined. Findings: There was significant difference between the ability of the two drugs to induce firm contraction of uterine muscle. The rate of firm contraction of uterine muscle in response to IV infusion of 10% dextrose was 68.3% and to IV infusion of 40 IU/L oxytocin was 31.7% (P < 0.01). IV infusion of 10% dextrose affected high parity women more intensely (82.4% compare to 12.5%) and IV infusion of 40 IU/L oxytocin had a more intense effect on low parity women (63.6% compare to 43.5%) (P> 0.05). Conclusion: IV infusion of 10% dextrose is more effective than IV infusion of 40 IU/L oxytocin on uterine bleeding and firm contraction of uterine muscle after cesarean section in the women.