EVALUATION OF ORAL PREGABALIN AND LOCAL ANESTHESIA: SIMULTANEOUS ADMINISTRATION EFFECT ON PAIN OF PATIENTS UNDERGOING PROSTATE BIOPSY REFERRED TO IMAM HOSPITAL OF URMIA

Abstract

Background & Aim: Prostate cancer is one of the most common cancers in men. This study investigates the effectiveness of oral pregabalin combined with local anesthesia in reducing pain for patients undergoing prostate biopsy. Materials & Methods: In this randomized clinical trial, 78 patients candidates for prostate biopsy were divided into two groups: the control group (local anesthesia with lidocaine) and the intervention group (100 mg oral pregabalin two hours before the procedure + local anesthesia). The biopsy was performed under rectal ultrasound guidance. Patients’ pain intensity was evaluated one and six hours post-biopsy using the Visual Analogue Scale (VAS). Results: The most common reason for referral in both groups was Lower Urinary Tract Symptoms (LUTS) (48.7% in the control group and 41% in the intervention group). Pain intensity was significantly lower in the intervention group compared to the control group (p<0.001). This difference was observed both at one hour and six hours post-procedure. Cigarette smoking had no significant effect on pain levels. Conclusion: Administration of 100 mg oral pregabalin two hours before prostate biopsy, combined with local anesthesia, results in a significant reduction in patient pain during the hours following the procedure. This finding could help improve patient experience and increase their acceptance of undergoing prostate biopsy.